GW405833 hydrochloride ( GW-405833;GW 405833 )

Catalog No. M10739 CAS No. 1202865-22-2

A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.

Purity : >98% (HPLC)

COA

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HPLC

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Biological Information

Product Name

GW405833 hydrochloride
Note

Research use only, not for human use.
Brief Description

A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
Description

A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1; causes a concentration-dependent inhibition of forskolin-mediated cAMP accumulation in CHO-K1 cells with EC50 of 0.65 nM, elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain.
Synonyms

GW-405833;GW 405833
Pathway

GPCR/G Protein
Target

Cannabinoid Receptor
Recptor

Cannabinoid Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1202865-22-2
Formula Weight

483.81
Molecular Formula

C23H25Cl3N2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

(2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone hydrochloride

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Valenzano KJ, et al. Neuropharmacology. 2005 Apr;48(5):658-72.
2. Whiteside GT, et al. Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72.
3. Hu B, et al. Pain. 2009 Jun;143(3):206-12.
4. Li AL, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):296-305.

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