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GW405833 hydrochloride

CAS No. 1202865-22-2

GW405833 hydrochloride( GW-405833 | GW 405833 )

Catalog No. M10739 CAS No. 1202865-22-2

A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GW405833 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1.
  • Description
    A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1; causes a concentration-dependent inhibition of forskolin-mediated cAMP accumulation in CHO-K1 cells with EC50 of 0.65 nM, elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GW-405833 | GW 405833
  • Pathway
    GPCR/G Protein
  • Target
    Cannabinoid Receptor
  • Recptor
    Cannabinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1202865-22-2
  • Formula Weight
    483.814
  • Molecular Formula
    C23H25Cl3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (258.36 mM)
  • SMILES
    ——
  • Chemical Name
    (2,3-dichloro-phenyl)-[5-methoxy-2-methyl-3-(2-morpholin-4-yl-ethyl)-indol-1-yl]-methanone hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Valenzano KJ, et al. Neuropharmacology. 2005 Apr;48(5):658-72. 2. Whiteside GT, et al. Eur J Pharmacol. 2005 Dec 28;528(1-3):65-72. 3. Hu B, et al. Pain. 2009 Jun;143(3):206-12. 4. Li AL, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):296-305.
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